A dicotyledon‐specific glutaredoxin GRXC1 family with dimer‐dependent redox regulation is functionally redundant with GRXC2
Identifieur interne : 001563 ( Main/Exploration ); précédent : 001562; suivant : 001564A dicotyledon‐specific glutaredoxin GRXC1 family with dimer‐dependent redox regulation is functionally redundant with GRXC2
Auteurs : Christophe Riondet [France] ; Jean Paul Desouris [France] ; Jocelyne Guilleminot Montoya [France] ; Yvette Chartier [France] ; Yves Meyer [France] ; Jean-Philippe Reichheld [France]Source :
- Plant, Cell & Environment [ 0140-7791 ] ; 2012-02.
English descriptors
- KwdEn :
Abstract
The major known function of glutaredoxins (Grxs) is to reduce disulphide bridges. Recently, some have also been shown to interact with iron–sulphur clusters. These can be classified in two subgroups: class II Grx are found in all living organisms and are implicated in assembly of iron–sulphur clusters, while class I Grx are represented by only two members known to form a holodimer structure containing a cluster in vitro, but with an unknown function different from class II. Here, we report that in eukaryotic plants, GRXC1 (class I) orthologs are exclusively present in dicotyledonous plants, suggesting a specific function. Indeed, in Arabidopsis thaliana, reducing activity of recombinant GRXC1 is regulated by redox‐dependent stability of the cluster. In planta, GRXC1 has been found predominantly in a holodimeric form, indicating the presence of the cluster in vivo. This suggests that GRXC1 acts as a redox sensor, reducing downstream pathways under oxidative conditions. GRXC2, the closest homolog of GRXC1, is unable to form a cluster in vitro. Knock‐out mutants in grxc1 or grxc2 are aphenotypic, but the double mutant produces a lethal phenotype at an early stage after pollinization, suggesting that GRXC1 and GRXC2 share redundant and vital functions.
Url:
DOI: 10.1111/j.1365-3040.2011.02355.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001B53
- to stream Istex, to step Curation: 001B52
- to stream Istex, to step Checkpoint: 000233
- to stream Main, to step Merge: 001578
- to stream Main, to step Curation: 001563
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A dicotyledon‐specific glutaredoxin GRXC1 family with dimer‐dependent redox regulation is functionally redundant with GRXC2</title>
<author><name sortKey="Riondet, Christophe" sort="Riondet, Christophe" uniqKey="Riondet C" first="Christophe" last="Riondet">Christophe Riondet</name>
</author>
<author><name sortKey="Desouris, Jean Paul" sort="Desouris, Jean Paul" uniqKey="Desouris J" first="Jean Paul" last="Desouris">Jean Paul Desouris</name>
</author>
<author><name sortKey="Montoya, Jocelyne Guilleminot" sort="Montoya, Jocelyne Guilleminot" uniqKey="Montoya J" first="Jocelyne Guilleminot" last="Montoya">Jocelyne Guilleminot Montoya</name>
</author>
<author><name sortKey="Chartier, Yvette" sort="Chartier, Yvette" uniqKey="Chartier Y" first="Yvette" last="Chartier">Yvette Chartier</name>
</author>
<author><name sortKey="Meyer, Yves" sort="Meyer, Yves" uniqKey="Meyer Y" first="Yves" last="Meyer">Yves Meyer</name>
</author>
<author><name sortKey="Reichheld, Jean Hilippe" sort="Reichheld, Jean Hilippe" uniqKey="Reichheld J" first="Jean-Philippe" last="Reichheld">Jean-Philippe Reichheld</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C6BFC8E899511A09D4BC9AD4A0DEB5CD204E6080</idno>
<date when="2012" year="2012">2012</date>
<idno type="doi">10.1111/j.1365-3040.2011.02355.x</idno>
<idno type="url">https://api.istex.fr/document/C6BFC8E899511A09D4BC9AD4A0DEB5CD204E6080/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001B53</idno>
<idno type="wicri:Area/Istex/Curation">001B52</idno>
<idno type="wicri:Area/Istex/Checkpoint">000233</idno>
<idno type="wicri:doubleKey">0140-7791:2012:Riondet C:a:dicotyledon:specific</idno>
<idno type="wicri:Area/Main/Merge">001578</idno>
<idno type="wicri:Area/Main/Curation">001563</idno>
<idno type="wicri:Area/Main/Exploration">001563</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A dicotyledon‐specific glutaredoxin GRXC1 family with dimer‐dependent redox regulation is functionally redundant with GRXC2</title>
<author><name sortKey="Riondet, Christophe" sort="Riondet, Christophe" uniqKey="Riondet C" first="Christophe" last="Riondet">Christophe Riondet</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Génome et Développement des Plantes, UMR 5096 CNRS‐UPVD, 58 Avenue de Villeneuve – Bat T, 66860 Perpignan Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Perpignan</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Desouris, Jean Paul" sort="Desouris, Jean Paul" uniqKey="Desouris J" first="Jean Paul" last="Desouris">Jean Paul Desouris</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Génome et Développement des Plantes, UMR 5096 CNRS‐UPVD, 58 Avenue de Villeneuve – Bat T, 66860 Perpignan Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Perpignan</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montoya, Jocelyne Guilleminot" sort="Montoya, Jocelyne Guilleminot" uniqKey="Montoya J" first="Jocelyne Guilleminot" last="Montoya">Jocelyne Guilleminot Montoya</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Génome et Développement des Plantes, UMR 5096 CNRS‐UPVD, 58 Avenue de Villeneuve – Bat T, 66860 Perpignan Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Perpignan</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chartier, Yvette" sort="Chartier, Yvette" uniqKey="Chartier Y" first="Yvette" last="Chartier">Yvette Chartier</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Génome et Développement des Plantes, UMR 5096 CNRS‐UPVD, 58 Avenue de Villeneuve – Bat T, 66860 Perpignan Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Perpignan</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meyer, Yves" sort="Meyer, Yves" uniqKey="Meyer Y" first="Yves" last="Meyer">Yves Meyer</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Génome et Développement des Plantes, UMR 5096 CNRS‐UPVD, 58 Avenue de Villeneuve – Bat T, 66860 Perpignan Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Perpignan</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reichheld, Jean Hilippe" sort="Reichheld, Jean Hilippe" uniqKey="Reichheld J" first="Jean-Philippe" last="Reichheld">Jean-Philippe Reichheld</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Génome et Développement des Plantes, UMR 5096 CNRS‐UPVD, 58 Avenue de Villeneuve – Bat T, 66860 Perpignan Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Perpignan</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Plant, Cell & Environment</title>
<idno type="ISSN">0140-7791</idno>
<idno type="eISSN">1365-3040</idno>
<imprint><publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="2012-02">2012-02</date>
<biblScope unit="volume">35</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="360">360</biblScope>
<biblScope unit="page" to="373">373</biblScope>
</imprint>
<idno type="ISSN">0140-7791</idno>
</series>
<idno type="istex">C6BFC8E899511A09D4BC9AD4A0DEB5CD204E6080</idno>
<idno type="DOI">10.1111/j.1365-3040.2011.02355.x</idno>
<idno type="ArticleID">PCE2355</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0140-7791</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arabidopsis</term>
<term>iron–sulphur</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The major known function of glutaredoxins (Grxs) is to reduce disulphide bridges. Recently, some have also been shown to interact with iron–sulphur clusters. These can be classified in two subgroups: class II Grx are found in all living organisms and are implicated in assembly of iron–sulphur clusters, while class I Grx are represented by only two members known to form a holodimer structure containing a cluster in vitro, but with an unknown function different from class II. Here, we report that in eukaryotic plants, GRXC1 (class I) orthologs are exclusively present in dicotyledonous plants, suggesting a specific function. Indeed, in Arabidopsis thaliana, reducing activity of recombinant GRXC1 is regulated by redox‐dependent stability of the cluster. In planta, GRXC1 has been found predominantly in a holodimeric form, indicating the presence of the cluster in vivo. This suggests that GRXC1 acts as a redox sensor, reducing downstream pathways under oxidative conditions. GRXC2, the closest homolog of GRXC1, is unable to form a cluster in vitro. Knock‐out mutants in grxc1 or grxc2 are aphenotypic, but the double mutant produces a lethal phenotype at an early stage after pollinization, suggesting that GRXC1 and GRXC2 share redundant and vital functions.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Languedoc-Roussillon</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Perpignan</li>
</settlement>
</list>
<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Riondet, Christophe" sort="Riondet, Christophe" uniqKey="Riondet C" first="Christophe" last="Riondet">Christophe Riondet</name>
</region>
<name sortKey="Chartier, Yvette" sort="Chartier, Yvette" uniqKey="Chartier Y" first="Yvette" last="Chartier">Yvette Chartier</name>
<name sortKey="Desouris, Jean Paul" sort="Desouris, Jean Paul" uniqKey="Desouris J" first="Jean Paul" last="Desouris">Jean Paul Desouris</name>
<name sortKey="Meyer, Yves" sort="Meyer, Yves" uniqKey="Meyer Y" first="Yves" last="Meyer">Yves Meyer</name>
<name sortKey="Montoya, Jocelyne Guilleminot" sort="Montoya, Jocelyne Guilleminot" uniqKey="Montoya J" first="Jocelyne Guilleminot" last="Montoya">Jocelyne Guilleminot Montoya</name>
<name sortKey="Reichheld, Jean Hilippe" sort="Reichheld, Jean Hilippe" uniqKey="Reichheld J" first="Jean-Philippe" last="Reichheld">Jean-Philippe Reichheld</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001563 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001563 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Bois |area= OrangerV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:C6BFC8E899511A09D4BC9AD4A0DEB5CD204E6080 |texte= A dicotyledon‐specific glutaredoxin GRXC1 family with dimer‐dependent redox regulation is functionally redundant with GRXC2 }}
This area was generated with Dilib version V0.6.25. |